Welcome to the Charvin Lab
The lab develops microfluidics-based single cell imaging assays to address several fundamental questions related to the control of proliferation and aging. Our favorite model organism is Saccharomyces cerevisiae but we also develop projects with Caenorhabditis elegans. We focus on the following main axis: First, we want to unravel the mechanisms that drive the entry into replicative senescence in budding yeast. Second, we develop quantitative analyses to decipher the complexity of the physiological response (I.e. redox signaling and growth control) to oxidative stress and starvation in yeast and nematodes. For this, the lab combines molecular genetics and live imaging with the exquisite environmental control provided by microfluidic devices to monitor the dynamics of these cellular processes with single cell resolution. We are based in IGBMC in Strasbourg (FRANCE) and part of the Development and stem cells department.
Recent Lab News
October 2021
Tired of counting divisions? Bored of segmenting cells manually? Do you want to stop spending your time clicking on cells? We might have something for you: DetecDiv.
September 2021
Théo attended and presented at the GDR-MNF conference, in Toulouse. Happy to see other scientists in-person again, especially in this beautiful city. Wonderful talks and friendly community, thank you GDR-MNF!
July 2021
How worms sense oxidative stress? Check out our pre-print !
April 2021
Unintuitively, oxidative stress response in budding yeast cells underlies a trade-off between redox homeostasis maintenance and stress survival! Check out our pre-print !
December 2020
Basile successfully defended his PhD thesis!
November 2020
How to follow single-cells throughout the whole life-cycle of the media? --> Check out our pre-print
August 2019
We greatly enjoyed the yeast2019 conference held in Gothenburg! A lot of interesting talks, posters and discussions.
July 2019
Did you know that ERC accumulation precedes the onset of physiological decline in aging yeast cells? Check this out in the latest paper from our lab!
June 2019
Tired of cloning ? Try COSPLAY, a new combinatorial toolbox for swift plasmid assembly in yeast!
May 2019
3D focusing of yeasts in microfluidics? Now super easy with our device.
March 2019
Great department retreat at Mittelwhir!
March 2019
The Charvin Lab website is born!
