Welcome to the Charvin Lab
The lab develops microfluidics-based single cell imaging assays to address several fundamental questions related to the control of proliferation and aging. Our favorite model organism is Saccharomyces cerevisiae but we also develop projects with Caenorhabditis elegans. We focus on the following main axis: First, we want to unravel the mechanisms that drive the entry into replicative senescence in budding yeast. Second, we develop quantitative analyses to decipher the complexity of the physiological response (I.e. redox signaling and growth control) to oxidative stress and starvation in yeast and nematodes. For this, the lab combines molecular genetics and live imaging with the exquisite environmental control provided by microfluidic devices to monitor the dynamics of these cellular processes with single cell resolution. We are based in IGBMC in Strasbourg, France.